SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia

Previously, we identified SETD2 loss-of-function mutations in 22% of MLL-rearranged (MLLr) acute leukemia patients, implicating a mechanism for cooperativity between SETD2 mutations and MLL fusions. However, the detailed mechanism of how SETD2-H3K36me3 downregulation accelerates MLLr leukemia remain...

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Gepubliceerd in:Leukemia
Hoofdauteurs: Bu, J, Chen, A, Yan, X, He, F, Dong, Y, Zhou, Y, He, J, Zhan, D, Lin, P, Hayashi, Y, Sun, Y, Zhang, Y, Xiao, Z, Grimes, HL, Wang, QF, Huang, G
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277029/
https://ncbi.nlm.nih.gov/pubmed/29249820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.339
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