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Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia
MLL-rearranged leukemia depends on H3K79 methylation. Depletion of this transcriptionally activating mark by DOT1L deletion or high concentrations of the inhibitor pinometostat downregulates HOXA9 and MEIS1, and consequently reduces leukemia survival. Yet, some MLL-rearranged leukemias are inexplica...
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| Veröffentlicht in: | eLife |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8315800/ https://ncbi.nlm.nih.gov/pubmed/34263728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64960 |
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