Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells

DNMT inhibitors are promising new drugs for cancer therapies. In this study, we have observed the antileukemic action of two diverse DNMT inhibitors, the nucleoside agent zebularine and the non-nucleoside agent RG108, in human promyelocytic leukemia (PML) HL-60 cells. Zebularine but not RG108 caused...

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Dettagli Bibliografici
Pubblicato in:Cell Mol Biol Lett
Autori principali: Savickiene, Jurate, Treigyte, Grazina, Borutinskaite, Veronika-Viktorija, Navakauskiene, Ruta
Natura: Artigo
Lingua:Inglês
Pubblicazione: SP Versita 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275587/
https://ncbi.nlm.nih.gov/pubmed/22820861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2478/s11658-012-0024-5
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