Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells

DNMT inhibitors are promising new drugs for cancer therapies. In this study, we have observed the antileukemic action of two diverse DNMT inhibitors, the nucleoside agent zebularine and the non-nucleoside agent RG108, in human promyelocytic leukemia (PML) HL-60 cells. Zebularine but not RG108 caused...

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Vydáno v:Cell Mol Biol Lett
Hlavní autoři: Savickiene, Jurate, Treigyte, Grazina, Borutinskaite, Veronika-Viktorija, Navakauskiene, Ruta
Médium: Artigo
Jazyk:Inglês
Vydáno: SP Versita 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275587/
https://ncbi.nlm.nih.gov/pubmed/22820861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2478/s11658-012-0024-5
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