Thymic epithelial cell support of thymopoiesis does not require Klotho

Age-related thymic involution is characterized by a decrease in thymic epithelial cell (TEC) number and function parallel to a disruption in their spatial organization, resulting in defective thymocyte development and proliferation as well as peripheral T cell dysfunction. Deficiency of Klotho, an a...

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Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Xing, Yan, Smith, Michelle J., Goetz, Christine A., McElmurry, Ron T., Parker, Sarah L., Min, Dullei, Hollander, Georg A., Weinberg, Kenneth I., Tolar, Jakub, Stefanski, Heather E., Blazar, Bruce R.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275142/
https://ncbi.nlm.nih.gov/pubmed/30373854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800670
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