T cell progenitor therapy–facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction

Infusion of in vitro–derived T cell progenitor (proT) therapy with hematopoietic stem cell transplant aids the recovery of the thymus damaged by total body irradiation. To understand the interaction between proTs and the thymic microenvironment, WT mice were lethally irradiated and given T cell–defi...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Smith, Michelle J., Reichenbach, Dawn K., Parker, Sarah L., Riddle, Megan J., Mitchell, Jason, Osum, Kevin C., Mohtashami, Mahmood, Stefanski, Heather E., Fife, Brian T., Bhandoola, Avinash, Hogquist, Kristin A., Holländer, Georg A., Zúñiga-Pflücker, Juan Carlos, Tolar, Jakub, Blazar, Bruce R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436538/
https://ncbi.nlm.nih.gov/pubmed/28515359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92056
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