T cell progenitor therapy–facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction

Infusion of in vitro–derived T cell progenitor (proT) therapy with hematopoietic stem cell transplant aids the recovery of the thymus damaged by total body irradiation. To understand the interaction between proTs and the thymic microenvironment, WT mice were lethally irradiated and given T cell–defi...

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發表在:JCI Insight
Main Authors: Smith, Michelle J., Reichenbach, Dawn K., Parker, Sarah L., Riddle, Megan J., Mitchell, Jason, Osum, Kevin C., Mohtashami, Mahmood, Stefanski, Heather E., Fife, Brian T., Bhandoola, Avinash, Hogquist, Kristin A., Holländer, Georg A., Zúñiga-Pflücker, Juan Carlos, Tolar, Jakub, Blazar, Bruce R.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2017
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436538/
https://ncbi.nlm.nih.gov/pubmed/28515359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92056
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