T cell progenitor therapy–facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction

Infusion of in vitro–derived T cell progenitor (proT) therapy with hematopoietic stem cell transplant aids the recovery of the thymus damaged by total body irradiation. To understand the interaction between proTs and the thymic microenvironment, WT mice were lethally irradiated and given T cell–defi...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Smith, Michelle J., Reichenbach, Dawn K., Parker, Sarah L., Riddle, Megan J., Mitchell, Jason, Osum, Kevin C., Mohtashami, Mahmood, Stefanski, Heather E., Fife, Brian T., Bhandoola, Avinash, Hogquist, Kristin A., Holländer, Georg A., Zúñiga-Pflücker, Juan Carlos, Tolar, Jakub, Blazar, Bruce R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436538/
https://ncbi.nlm.nih.gov/pubmed/28515359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92056
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