Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis

The integrated stress response (ISR) pathway is essential for adaption of various stresses and is related to mitochondrion-to-nucleus communication. Mitochondrial dysfunction-induced reactive oxygen species (ROS) was demonstrated to activate general control nonderepressible 2 (GCN2)–eukaryotic trans...

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Detaylı Bibliyografya
Yayımlandı:Int J Mol Sci
Asıl Yazarlar: Wang, Sheng-Fan, Wung, Chih-Hsuan, Chen, Meng-Shian, Chen, Chian-Feng, Yin, Pen-Hui, Yeh, Tien-Shun, Chang, Yuh-Lih, Chou, Yueh-Ching, Hung, Hung-Hsu, Lee, Hsin-Chen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275069/
https://ncbi.nlm.nih.gov/pubmed/30380689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19113389
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