Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis

The integrated stress response (ISR) pathway is essential for adaption of various stresses and is related to mitochondrion-to-nucleus communication. Mitochondrial dysfunction-induced reactive oxygen species (ROS) was demonstrated to activate general control nonderepressible 2 (GCN2)–eukaryotic trans...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Wang, Sheng-Fan, Wung, Chih-Hsuan, Chen, Meng-Shian, Chen, Chian-Feng, Yin, Pen-Hui, Yeh, Tien-Shun, Chang, Yuh-Lih, Chou, Yueh-Ching, Hung, Hung-Hsu, Lee, Hsin-Chen
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275069/
https://ncbi.nlm.nih.gov/pubmed/30380689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19113389
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