Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis

The integrated stress response (ISR) pathway is essential for adaption of various stresses and is related to mitochondrion-to-nucleus communication. Mitochondrial dysfunction-induced reactive oxygen species (ROS) was demonstrated to activate general control nonderepressible 2 (GCN2)–eukaryotic trans...

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Publicat a:Int J Mol Sci
Autors principals: Wang, Sheng-Fan, Wung, Chih-Hsuan, Chen, Meng-Shian, Chen, Chian-Feng, Yin, Pen-Hui, Yeh, Tien-Shun, Chang, Yuh-Lih, Chou, Yueh-Ching, Hung, Hung-Hsu, Lee, Hsin-Chen
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275069/
https://ncbi.nlm.nih.gov/pubmed/30380689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19113389
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