CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway

Cancer cells exhibit an abnormal amino acid metabolism and a dependence on specific amino acids, which might provide potential targets for treating cancer patients. In this study, we demonstrated that human triple negative breast cancer (TNBC) cells were highly susceptible to cystine starvation. We...

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Publicat a:Oncotarget
Autors principals: Chen, Meng-Shian, Wang, Sheng-Fan, Hsu, Chih-Yi, Yin, Pen-Hui, Yeh, Tien-Shun, Lee, Hsin-Chen, Tseng, Ling-Ming
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777716/
https://ncbi.nlm.nih.gov/pubmed/29383104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23055
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