CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway

Cancer cells exhibit an abnormal amino acid metabolism and a dependence on specific amino acids, which might provide potential targets for treating cancer patients. In this study, we demonstrated that human triple negative breast cancer (TNBC) cells were highly susceptible to cystine starvation. We...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Chen, Meng-Shian, Wang, Sheng-Fan, Hsu, Chih-Yi, Yin, Pen-Hui, Yeh, Tien-Shun, Lee, Hsin-Chen, Tseng, Ling-Ming
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777716/
https://ncbi.nlm.nih.gov/pubmed/29383104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23055
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