The eIF2α kinase GCN2 modulates period and rhythmicity of the circadian clock by translational control of Atf4

The integrated stress response (ISR) is activated in response to diverse stress stimuli to maintain homeostasis in neurons. Central to this process is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α). Here we report a critical role for ISR in regulating the mammalian c...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Pathak, Salil Saurav, Liu, Dong, Li, Tianbao, de Zavalia, Nuria, Zhu, Lei, Li, Jin, Karthikeyan, Ramanujam, Alain, Tommy, Liu, Andrew C., Storch, Kai-Florian, Kaufman, Randal J., Jin, Victor X., Amir, Shimon, Sonenberg, Nahum, Cao, Ruifeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6872934/
https://ncbi.nlm.nih.gov/pubmed/31522764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.08.007
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados