The eIF2α kinase GCN2 modulates period and rhythmicity of the circadian clock by translational control of Atf4

The integrated stress response (ISR) is activated in response to diverse stress stimuli to maintain homeostasis in neurons. Central to this process is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α). Here we report a critical role for ISR in regulating the mammalian c...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Neuron
Main Authors: Pathak, Salil Saurav, Liu, Dong, Li, Tianbao, de Zavalia, Nuria, Zhu, Lei, Li, Jin, Karthikeyan, Ramanujam, Alain, Tommy, Liu, Andrew C., Storch, Kai-Florian, Kaufman, Randal J., Jin, Victor X., Amir, Shimon, Sonenberg, Nahum, Cao, Ruifeng
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6872934/
https://ncbi.nlm.nih.gov/pubmed/31522764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.08.007
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker