mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction

Mammalian/mechanistic target of rapamycin (mTOR) signaling controls cell growth, proliferation, and metabolism in dividing cells. Less is known regarding its function in postmitotic neurons in the adult brain. Here we created a conditional mTOR knockout mouse model to address this question. Using th...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Liu, Dong, Stowie, Adam, de Zavalia, Nuria, Leise, Tanya, Pathak, Salil Saurav, Drewes, Lester R., Davidson, Alec J., Amir, Shimon, Sonenberg, Nahum, Cao, Ruifeng
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889665/
https://ncbi.nlm.nih.gov/pubmed/29555746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721578115
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