mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction

Mammalian/mechanistic target of rapamycin (mTOR) signaling controls cell growth, proliferation, and metabolism in dividing cells. Less is known regarding its function in postmitotic neurons in the adult brain. Here we created a conditional mTOR knockout mouse model to address this question. Using th...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liu, Dong, Stowie, Adam, de Zavalia, Nuria, Leise, Tanya, Pathak, Salil Saurav, Drewes, Lester R., Davidson, Alec J., Amir, Shimon, Sonenberg, Nahum, Cao, Ruifeng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889665/
https://ncbi.nlm.nih.gov/pubmed/29555746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721578115
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