mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction

Mammalian/mechanistic target of rapamycin (mTOR) signaling controls cell growth, proliferation, and metabolism in dividing cells. Less is known regarding its function in postmitotic neurons in the adult brain. Here we created a conditional mTOR knockout mouse model to address this question. Using th...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Liu, Dong, Stowie, Adam, de Zavalia, Nuria, Leise, Tanya, Pathak, Salil Saurav, Drewes, Lester R., Davidson, Alec J., Amir, Shimon, Sonenberg, Nahum, Cao, Ruifeng
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889665/
https://ncbi.nlm.nih.gov/pubmed/29555746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721578115
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