The eIF2α kinase GCN2 modulates period and rhythmicity of the circadian clock by translational control of Atf4

The integrated stress response (ISR) is activated in response to diverse stress stimuli to maintain homeostasis in neurons. Central to this process is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α). Here we report a critical role for ISR in regulating the mammalian c...

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Gepubliceerd in:Neuron
Hoofdauteurs: Pathak, Salil Saurav, Liu, Dong, Li, Tianbao, de Zavalia, Nuria, Zhu, Lei, Li, Jin, Karthikeyan, Ramanujam, Alain, Tommy, Liu, Andrew C., Storch, Kai-Florian, Kaufman, Randal J., Jin, Victor X., Amir, Shimon, Sonenberg, Nahum, Cao, Ruifeng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6872934/
https://ncbi.nlm.nih.gov/pubmed/31522764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.08.007
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