Synthesis and Structure-Activity Relationships of Imidazole-Coumarin Conjugates against Hepatitis C Virus

A series of new conjugated compounds with a –SCH(2)– linkage were synthesized by chemical methods from imidazole and coumarin derivatives. The experimental results indicate that of the twenty newly synthesized imidazole–coumarin conjugates, three of them exhibited appealing EC(50) values (5.1–8.4 μM...

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Pubblicato in:Molecules
Autori principali: Tsay, Shwu-Chen, Lin, Shu-Yu, Huang, Wen-Chieh, Hsu, Ming-Hua, Hwang, Kuo Chu, Lin, Chun-Cheng, Horng, Jia-Cherng, Chen, I-Chia, Hwu, Jih Ru, Shieh, Fa-Kuen, Leyssen, Pieter, Neyts, Johan
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273635/
https://ncbi.nlm.nih.gov/pubmed/26901180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21020228
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