Synthesis and Structure-Activity Relationships of Imidazole-Coumarin Conjugates against Hepatitis C Virus

A series of new conjugated compounds with a –SCH(2)– linkage were synthesized by chemical methods from imidazole and coumarin derivatives. The experimental results indicate that of the twenty newly synthesized imidazole–coumarin conjugates, three of them exhibited appealing EC(50) values (5.1–8.4 μM...

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Publicado no:Molecules
Main Authors: Tsay, Shwu-Chen, Lin, Shu-Yu, Huang, Wen-Chieh, Hsu, Ming-Hua, Hwang, Kuo Chu, Lin, Chun-Cheng, Horng, Jia-Cherng, Chen, I-Chia, Hwu, Jih Ru, Shieh, Fa-Kuen, Leyssen, Pieter, Neyts, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273635/
https://ncbi.nlm.nih.gov/pubmed/26901180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21020228
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