Synthesis and Structure-Activity Relationships of Imidazole-Coumarin Conjugates against Hepatitis C Virus

A series of new conjugated compounds with a –SCH(2)– linkage were synthesized by chemical methods from imidazole and coumarin derivatives. The experimental results indicate that of the twenty newly synthesized imidazole–coumarin conjugates, three of them exhibited appealing EC(50) values (5.1–8.4 μM...

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書誌詳細
出版年:Molecules
主要な著者: Tsay, Shwu-Chen, Lin, Shu-Yu, Huang, Wen-Chieh, Hsu, Ming-Hua, Hwang, Kuo Chu, Lin, Chun-Cheng, Horng, Jia-Cherng, Chen, I-Chia, Hwu, Jih Ru, Shieh, Fa-Kuen, Leyssen, Pieter, Neyts, Johan
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273635/
https://ncbi.nlm.nih.gov/pubmed/26901180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21020228
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