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Drug-Induced Conformational Population Shifts in Topoisomerase-DNA Ternary Complexes
Type II topoisomerases (TOP2) are enzymes that resolve the topological problems during DNA replication and transcription by transiently cleaving both strands and forming a cleavage complex with the DNA. Several prominent anti-cancer agents inhibit TOP2 by stabilizing the cleavage complex and engende...
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| Publicado no: | Molecules |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6272011/ https://ncbi.nlm.nih.gov/pubmed/24905608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules19067415 |
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