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Contributions of the D-Ring to the Activity of Etoposide Against Human Topoisomerase IIα: Potential Interactions with DNA in the Ternary Enzyme-Drug-DNA Complex
Etoposide is a widely prescribed anticancer drug that stabilizes covalent topoisomerase II-cleaved DNA complexes. The drug contains a polycyclic ring system (rings A–D), a glycosidic moiety at C4, and a pendant ring (E–ring) at C1. Interactions between human topoisomerase IIα and etoposide in the bi...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3109987/ https://ncbi.nlm.nih.gov/pubmed/21548574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200531q |
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