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Substituents on Etoposide that Interact with Human Topoisomerase IIα in the Binary Enzyme-Drug Complex: Contributions to Etoposide Binding and Activity
Etoposide is a widely prescribed anticancer agent that stabilizes topoisomerase II-mediated DNA strand breaks. The drug contains a polycyclic ring system (rings A–D), a glycosidic moiety at C4, and a pendant ring (E–ring) at C1. A recent study that focused on yeast topoisomerase II demonstrated that...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2737519/ https://ncbi.nlm.nih.gov/pubmed/18355043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi702019z |
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