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Bidirectional DNA unwinding by a ternary complex of T antigen, nucleolin and topoisomerase I

The simian virus 40 large tumour-antigen (T antigen) DNA helicase is a hexameric structure; it has been proposed that, in viral DNA replication, two of these hexamers are combined to form a bipartite holoenzyme that acts concurrently at both forks of a replication bubble. In a search for structural...

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Detalhes bibliográficos
Main Authors: Seinsoth, Stephanie, Uhlmann-Schiffler, Heike, Stahl, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315898/
https://ncbi.nlm.nih.gov/pubmed/12634843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor770
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