Nilotinib Enhances the Efficacy of Conventional Chemotherapeutic Drugs in CD34(+)CD38(−) Stem Cells and ABC Transporter Overexpressing Leukemia Cells

Incomplete chemotherapeutic eradication of leukemic CD34(+)CD38(−) stem cells is likely to result in disease relapse. The purpose of this study was to evaluate the effect of nilotinib on eradicating leukemia stem cells and enhancing the efficacy of chemotherapeutic agents. Our results showed that AB...

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Veröffentlicht in:Molecules
Hauptverfasser: Wang, Fang, Wang, Xiao-Kun, Shi, Cheng-Jun, Zhang, Hui, Hu, Ya-Peng, Chen, Yi-Fan, Fu, Li-Wu
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6270868/
https://ncbi.nlm.nih.gov/pubmed/24651611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules19033356
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