Nilotinib interferes with cell cycle, ABC transporters and JAK-STAT signaling pathway in CD34+/lin- cells of patients with chronic phase chronic myeloid leukemia after 12 months of treatment

Chronic myeloid leukemia (CML) is characterized by the constitutive tyrosine kinase activity of the oncoprotein BCR-ABL1 in myeloid progenitor cells that activates multiple signal transduction pathways leading to the leukemic phenotype. The tyrosine-kinase inhibitor (TKI) nilotinib inhibits the tyro...

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Veröffentlicht in:PLoS One
Hauptverfasser: Trojani, Alessandra, Pungolino, Ester, Dal Molin, Alessandra, Lodola, Milena, Rossi, Giuseppe, D’Adda, Mariella, Perego, Alessandra, Elena, Chiara, Turrini, Mauro, Borin, Lorenza, Bucelli, Cristina, Malato, Simona, Carraro, Maria Cristina, Spina, Francesco, Latargia, Maria Luisa, Artale, Salvatore, Spedini, Pierangelo, Anghilieri, Michela, Di Camillo, Barbara, Baruzzo, Giacomo, De Canal, Gabriella, Iurlo, Alessandra, Morra, Enrica, Cairoli, Roberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6638825/
https://ncbi.nlm.nih.gov/pubmed/31318870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0218444
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