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Therapeutic potential of carbonyl-scavenging carnosine derivative in metabolic disorders

Obesity and overnutrition increase levels of reactive sugar- and lipid-derived aldehydes called reactive carbonyl species (RCS). Increased tissue and circulating RCS levels have been tied to insulin resistance and inflammation, but previous pharmacological approaches to target RCS have had equivocal...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Haus, Jacob M., Thyfault, John P.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264722/
https://ncbi.nlm.nih.gov/pubmed/30352430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124304
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