Population Pharmacokinetics of Apixaban in Subjects With Nonvalvular Atrial Fibrillation

This analysis describes the population pharmacokinetics (PPK) of apixaban in nonvalvular atrial fibrillation (NVAF) subjects, and quantifies the impact of intrinsic and extrinsic factors on exposure. The PPK model was developed using data from phase I–III studies. Apixaban exposure was characterized...

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Dades bibliogràfiques
Publicat a:CPT Pharmacometrics Syst Pharmacol
Autors principals: Cirincione, Brenda, Kowalski, Kenneth, Nielsen, Jace, Roy, Amit, Thanneer, Neelima, Byon, Wonkyung, Boyd, Rebecca, Wang, Xiaoli, Leil, Tarek, LaCreta, Frank, Ueno, Takayo, Oishi, Masayo, Frost, Charles
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6263664/
https://ncbi.nlm.nih.gov/pubmed/30259707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12347
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