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Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress

Reduced choroidal blood flow and tissue changes in the ageing human eye impair oxygen delivery to photoreceptors and the retinal pigment epithelium. As a consequence, mild but chronic hypoxia may develop and disturb cell metabolism, function and ultimately survival, potentially contributing to retin...

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Bibliografische gegevens
Gepubliceerd in:Cell Death Differ
Hoofdauteurs: Barben, Maya, Ail, Divya, Storti, Federica, Klee, Katrin, Schori, Christian, Samardzija, Marijana, Michalakis, Stylianos, Biel, Martin, Meneau, Isabelle, Blaser, Frank, Barthelmes, Daniel, Grimm, Christian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261999/
https://ncbi.nlm.nih.gov/pubmed/29666476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0094-7
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