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Intramembrane ionic protein–lipid interaction regulates integrin structure and function

Protein transmembrane domains (TMDs) are generally hydrophobic, but our bioinformatics analysis shows that many TMDs contain basic residues at terminal regions. Physiological functions of these membrane-snorkeling basic residues are largely unclear. Here, we show that a membrane-snorkeling Lys resid...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS Biol
Hauptverfasser: Guo, Jun, Zhang, Youhua, Li, Hua, Chu, Huiying, Wang, Qinshu, Jiang, Shutan, Li, Yan, Shen, Hongbin, Li, Guohui, Chen, Jianfeng, Xu, Chenqi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261646/
https://ncbi.nlm.nih.gov/pubmed/30427828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006525
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