Ionic CD3−Lck interaction regulates the initiation of T-cell receptor signaling

Antigen-triggered T-cell receptor (TCR) phosphorylation is the first signaling event in T cells to elicit adaptive immunity against invading pathogens and tumor cells. Despite its physiological importance, the underlying mechanism of TCR phosphorylation remains elusive. Here, we report a key mechani...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Li, Lunyi, Guo, Xingdong, Shi, Xiaoshan, Li, Changting, Wu, Wei, Yan, Chengsong, Wang, Haopeng, Li, Hua, Xu, Chenqi
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530670/
https://ncbi.nlm.nih.gov/pubmed/28659468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701990114
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