Structure-based evolution of low nanomolar O-GlcNAc transferase inhibitors

Reversible glycosylation of nuclear and cytoplasmic proteins is an important regulatory mechanism across metazoans. One enzyme, O-linked N-acetylglucosamine transferase (OGT), is responsible for all nucleocytoplasmic glycosylation and there is a well-known need for potent, cell-permeable inhibitors...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Martin, Sara E.S., Tan, Zhi-Wei, Itkonen, Harri M., Duveau, Damien Y., Paulo, Joao A., Janetzko, John, Boutz, Paul L., Törk, Lisa, Moss, Frederick A., Thomas, Craig J., Gygi, Steven P., Lazarus, Michael B., Walker, Suzanne
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261342/
https://ncbi.nlm.nih.gov/pubmed/30285435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b07328
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