Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism

Metabolic networks are highly connected and complex, but a single enzyme, O-GlcNAc transferase (OGT) can sense the availability of metabolites and also modify target proteins. We show that inhibition of OGT activity inhibits the proliferation of prostate cancer cells, leads to sustained loss of c-MY...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Itkonen, Harri M., Gorad, Saurabh S., Duveau, Damien Y., Martin, Sara E.S., Barkovskaya, Anna, Bathen, Tone F., Moestue, Siver A., Mills, Ian G.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914298/
https://ncbi.nlm.nih.gov/pubmed/26824323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7039
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