O-GlcNAc regulates gene expression by controlling detained intron splicing

Intron detention in precursor RNAs serves to regulate expression of a substantial fraction of genes in eukaryotic genomes. How detained intron (DI) splicing is controlled is poorly understood. Here, we show that a ubiquitous post-translational modification called O-GlcNAc, which is thought to integr...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Tan, Zhi-Wei, Fei, George, Paulo, Joao A, Bellaousov, Stanislav, Martin, Sara E S, Duveau, Damien Y, Thomas, Craig J, Gygi, Steven P, Boutz, Paul L, Walker, Suzanne
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261177/
https://ncbi.nlm.nih.gov/pubmed/32329777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa263
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