A Conserved Splicing Silencer Dynamically Regulates O-GlcNAc Transferase Intron Retention and O-GlcNAc Homeostasis

Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular processes and has been linked to human diseases. The enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) add and remove O-GlcNAc, but the mechanisms regulating their expression remain unclear. Here, we...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Park, Sung-Kyun, Zhou, Xiaorong, Pendleton, Kathryn E., Hunter, Olga V., Kohler, Jennifer J., O'Donnell, Kathryn A., Conrad, Nicholas K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588854/
https://ncbi.nlm.nih.gov/pubmed/28768194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.07.017
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