Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists

Drugs that treat chronic obstructive pulmonary disease by antagonizing the M3 muscarinic acetylcholine receptor (M3R) have had a significant effect on health, but can suffer from their lack of selectivity against the M2R subtype, which modulates heart rate. Beginning with the crystal structures of M...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Liu, Hongtao, Hofmann, Josefa, Fish, Inbar, Schaake, Benjamin, Eitel, Katrin, Bartuschat, Amelie, Kaindl, Jonas, Rampp, Hannelore, Banerjee, Ashutosh, Hübner, Harald, Clark, Mary J., Vincent, Sandra G., Fisher, John T., Heinrich, Markus R., Hirata, Kunio, Liu, Xiangyu, Sunahara, Roger K., Shoichet, Brian K., Kobilka, Brian K., Gmeiner, Peter
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255194/
https://ncbi.nlm.nih.gov/pubmed/30404914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813988115
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars