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Allosteric landscapes of eukaryotic cytoplasmic Hsp70s are shaped by evolutionary tuning of key interfaces

The 70-kDa heat shock proteins (Hsp70s) are molecular chaperones that perform a wide range of critical cellular functions. They assist in the folding of newly synthesized proteins, facilitate assembly of specific protein complexes, shepherd proteins across membranes, and prevent protein misfolding a...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Meng, Wenli, Clerico, Eugenia M., McArthur, Natalie, Gierasch, Lila M.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255180/
https://ncbi.nlm.nih.gov/pubmed/30397123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811105115
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