Key features of an Hsp70 chaperone allosteric landscape revealed by ion-mobility native mass spectrometry and double electron-electron resonance

Proteins are dynamic entities that populate conformational ensembles, and most functions of proteins depend on their dynamic character. Allostery, in particular, relies on ligand-modulated shifts in these conformational ensembles. Hsp70s are allosteric molecular chaperones with conformational landsc...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lai, Alex L., Clerico, Eugenia M., Blackburn, Mandy E., Patel, Nisha A., Robinson, Carol V., Borbat, Peter P., Freed, Jack H., Gierasch, Lila M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448104/
https://ncbi.nlm.nih.gov/pubmed/28428246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.770404
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