Llwytho...
An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones
The allosteric mechanism of Hsp70 molecular chaperones enables ATP binding to the N-terminal nucleotide-binding domain (NBD) to alter substrate affinity to the C-terminal substrate-binding domain (SBD), and substrate binding to enhance ATP hydrolysis. Cycling between ATP-bound and ADP-/substrate-bou...
Wedi'i Gadw mewn:
| Prif Awduron: | , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2012
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3521165/ https://ncbi.nlm.nih.gov/pubmed/23217711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.11.002 |
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