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Hsp70 chaperone ligands control domain association via an allosteric mechanism mediated by the interdomain linker
Hsp70 chaperones assist in protein folding, disaggregation and membrane translocation by binding to substrate proteins with an ATP-regulated affinity that relies on allosteric coupling between ATP-binding and substrate-binding domains. We have studied single and two-domain versions of the E. coli Hs...
में बचाया:
| मुख्य लेखकों: | , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2007
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1894942/ https://ncbi.nlm.nih.gov/pubmed/17434124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.02.020 |
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