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The Hsp70 interdomain linker is a dynamic switch that enables allosteric communication between two structured domains

Hsp70 molecular chaperones play key roles in cellular protein homeostasis by binding to exposed hydrophobic regions of incompletely folded or aggregated proteins. This crucial Hsp70 function relies on allosteric communication between two well-structured domains: an N-terminal nucleotide-binding doma...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: English, Charles A., Sherman, Woody, Meng, Wenli, Gierasch, Lila M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592658/
https://ncbi.nlm.nih.gov/pubmed/28754691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.789313
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