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The Hsp70 interdomain linker is a dynamic switch that enables allosteric communication between two structured domains
Hsp70 molecular chaperones play key roles in cellular protein homeostasis by binding to exposed hydrophobic regions of incompletely folded or aggregated proteins. This crucial Hsp70 function relies on allosteric communication between two well-structured domains: an N-terminal nucleotide-binding doma...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Biol Chem |
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| Prif Awduron: | , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Society for Biochemistry and Molecular Biology
2017
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5592658/ https://ncbi.nlm.nih.gov/pubmed/28754691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.789313 |
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