Chargement en cours...
An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones
The allosteric mechanism of Hsp70 molecular chaperones enables ATP binding to the N-terminal nucleotide-binding domain (NBD) to alter substrate affinity to the C-terminal substrate-binding domain (SBD), and substrate binding to enhance ATP hydrolysis. Cycling between ATP-bound and ADP-/substrate-bou...
Enregistré dans:
| Auteurs principaux: | , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3521165/ https://ncbi.nlm.nih.gov/pubmed/23217711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.11.002 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|