Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy

Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of chemotherapy by gene transfer, thus enabling target cells to convert non-toxic prodrugs to cytotoxic drugs. A zone of cell kill around gene-modified cells due to transfer of toxic metabolites, known as the byst...

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Enregistré dans:
Détails bibliographiques
Publié dans:Molecules
Auteurs principaux: Dachs, Gabi U., Hunt, Michelle A., Syddall, Sophie, Singleton, Dean C., Patterson, Adam V.
Format: Artigo
Langue:Inglês
Publié: Molecular Diversity Preservation International 2009
Sujets:
Review
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255103/
https://ncbi.nlm.nih.gov/pubmed/19924084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules14114517
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