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Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function
GBA1 encodes the lysosomal enzyme β-glucocerebrosidase (GCase) which converts glucosylceramide into ceramide and glucose. Mutations in GBA1 lead to Gaucher’s disease and are a major risk factor for Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB), synucleinopathies characterized by accum...
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| Pubblicato in: | Hum Mol Genet |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6251682/ https://ncbi.nlm.nih.gov/pubmed/29579237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy105 |
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