α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism

BACKGROUND: Mutations in glucocerebrosidase (GBA) cause Gaucher disease (GD) and increase the risk of developing Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). Since both genetic and environmental factors contribute to the pathogenesis of sporadic PD, we investigated the susceptibilit...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Yun, Seung Pil, Kim, Donghoon, Kim, Sangjune, Kim, SangMin, Karuppagounder, Senthilkumar S., Kwon, Seung-Hwan, Lee, Saebom, Kam, Tae-In, Lee, Suhyun, Ham, Sangwoo, Park, Jae Hong, Dawson, Valina L., Dawson, Ted M., Lee, Yunjong, Ko, Han Seok
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759291/
https://ncbi.nlm.nih.gov/pubmed/29310663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0233-5
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