α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism

BACKGROUND: Mutations in glucocerebrosidase (GBA) cause Gaucher disease (GD) and increase the risk of developing Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). Since both genetic and environmental factors contribute to the pathogenesis of sporadic PD, we investigated the susceptibilit...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Neurodegener
Prif Awduron: Yun, Seung Pil, Kim, Donghoon, Kim, Sangjune, Kim, SangMin, Karuppagounder, Senthilkumar S., Kwon, Seung-Hwan, Lee, Saebom, Kam, Tae-In, Lee, Suhyun, Ham, Sangwoo, Park, Jae Hong, Dawson, Valina L., Dawson, Ted M., Lee, Yunjong, Ko, Han Seok
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759291/
https://ncbi.nlm.nih.gov/pubmed/29310663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0233-5
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