α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism

BACKGROUND: Mutations in glucocerebrosidase (GBA) cause Gaucher disease (GD) and increase the risk of developing Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). Since both genetic and environmental factors contribute to the pathogenesis of sporadic PD, we investigated the susceptibilit...

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書誌詳細
出版年:Mol Neurodegener
主要な著者: Yun, Seung Pil, Kim, Donghoon, Kim, Sangjune, Kim, SangMin, Karuppagounder, Senthilkumar S., Kwon, Seung-Hwan, Lee, Saebom, Kam, Tae-In, Lee, Suhyun, Ham, Sangwoo, Park, Jae Hong, Dawson, Valina L., Dawson, Ted M., Lee, Yunjong, Ko, Han Seok
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2018
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759291/
https://ncbi.nlm.nih.gov/pubmed/29310663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0233-5
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