Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration

Aggregation of α-synuclein contributes to the formation of Lewy bodies and neurites, the pathologic hallmarks of Parkinson disease (PD) and α-synucleinopathies. Although a number of human mutations have been identified in familial PD, the mechanisms that promote α-synuclein accumulation and toxicity...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Brahmachari, Saurav, Ge, Preston, Lee, Su Hyun, Kim, Donghoon, Karuppagounder, Senthilkumar S., Kumar, Manoj, Mao, Xiaobo, Shin, Joo Ho, Lee, Yunjong, Pletnikova, Olga, Troncoso, Juan C., Dawson, Valina L., Dawson, Ted M., Ko, Han Seok
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966315/
https://ncbi.nlm.nih.gov/pubmed/27348587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85456
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