Poly (ADP-ribose) Drives Pathologic α-Synuclein Neurodegeneration in Parkinson’s Disease.

The pathologic accumulation and aggregation of α-synuclein (α-syn) underlies Parkinson’s disease (PD). The molecular mechanisms by which pathologic α-syn causes neurodegeneration in PD is not known. Here we found that pathologic α-syn activates poly (ADP-ribose) (PAR) polymerase-1 (PARP-1) and PAR g...

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Publicat a:Science
Autors principals: Kam, Tae-In, Mao, Xiaobo, Park, Hyejin, Chou, Shih-Ching, Karuppagounder, Senthilkumar S., Umanah, George Essien, Yun, Seung Pil, Brahmachari, Saurav, Panicker, Nikhil, Chen, Rong, Andrabi, Shaida A., Qi, Chen, Poirier, Guy G., Pletnikova, Olga, Troncoso, Juan C., Bekris, Lynn M., Leverenz, James B., Pantelyat, Alexander, Ko, Han Seok, Rosenthal, Liana S., Dawson, Ted M., Dawson, Valina L.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431793/
https://ncbi.nlm.nih.gov/pubmed/30385548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat8407
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