GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

Accumulating evidence suggests that α-synuclein (α-syn) occurs physiologically as a helically folded tetramer that resists aggregation. However, the mechanisms underlying the regulation of formation of α-syn tetramers are still mostly unknown. Cellular membrane lipids are thought to play an importan...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kim, Sangjune, Yun, Seung Pil, Lee, Saebom, Umanah, George Essien, Bandaru, Veera Venkata Ratnam, Yin, Xiling, Rhee, Peter, Karuppagounder, Senthilkumar S., Kwon, Seung-Hwan, Lee, Hojae, Mao, Xiaobo, Kim, Donghoon, Pandey, Akhilesh, Lee, Gabsang, Dawson, Valina L., Dawson, Ted M., Ko, Han Seok
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789900/
https://ncbi.nlm.nih.gov/pubmed/29311330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700465115
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