Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation

Genetic and biochemical abnormalities of α-synuclein are associated with the pathogenesis of Parkinson's disease. In the present study we investigated the in vivo interaction of mouse and human α-synuclein with the potent parkinsonian neurotoxin, MPTP. We find that while lack of mouse α-synucle...

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Detalhes bibliográficos
Principais autores: Thomas, Bobby, Mandir, Allen S., West, Neva, Liu, Ying, Andrabi, Shaida A., Stirling, Wanda, Dawson, Valina L., Dawson, Ted M., Lee, Michael K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031616/
https://ncbi.nlm.nih.gov/pubmed/21304957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016706
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