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Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation

When untransformed human cells spend >1.5 h in prometaphase under standard culture conditions, all daughters arrest in G1 despite normal division of their mothers. We investigate what happens during prolonged prometaphase that leads to daughter cell arrest in the absence of DNA damage. We find th...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Biol Cell
Prif Awduron: Uetake, Yumi, Sluder, Greenfield
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Cell Biology 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249836/
https://ncbi.nlm.nih.gov/pubmed/30133342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-01-0026
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