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Prolonged prometaphase blocks daughter cell proliferation despite normal completion of mitosis

The mitotic checkpoint maintains genomic stability by blocking the metaphase-anaphase transition until all kinetochores attach to spindle microtubules [1, 2]. However, some defects are not detected by this checkpoint. With low concentrations of microtubule targeting agents the checkpoint eventually...

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Bibliografiske detaljer
Main Authors: Uetake, Yumi, Sluder, Greenfield
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946429/
https://ncbi.nlm.nih.gov/pubmed/20832310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2010.08.018
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