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Prolonged prometaphase blocks daughter cell proliferation despite normal completion of mitosis
The mitotic checkpoint maintains genomic stability by blocking the metaphase-anaphase transition until all kinetochores attach to spindle microtubules [1, 2]. However, some defects are not detected by this checkpoint. With low concentrations of microtubule targeting agents the checkpoint eventually...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2946429/ https://ncbi.nlm.nih.gov/pubmed/20832310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2010.08.018 |
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